Arena Pharmaceuticals' Presence at United European Gastroenterology Week Strengthens Ongoing Commitment to the Gastrointestinal Disease Community
Arena Sponsored Symposium Details:
Title: Opening the Door to Emerging Investigational Treatments in Ulcerative Colitis: What Awaits Us?
Intended Audience: This symposium is designed for non-US healthcare professionals and is not affiliated with UEGW
Speakers: William Sandborn, MD (Chair), Professor
Day/Time: Monday, October 12 at
Title: Early and Durable Symptom Control in Patients with Moderately to Severely Active Ulcerative Colitis Treated with Etrasimod in the Randomised, Double Blind, Placebo Controlled, Phase 2 OASIS Trial and Open Label Extension
Day/Time: Tuesday, October 13, 2020, from
Title: Expression of Cannabinoid Receptors and the Effect of Olorinab, a Peripherally Acting, Highly Selective, Full Agonist of the Cannabinoid Receptor 2, on Visceral Hypersensitivity in Rodent Models of Irritable Bowel Syndrome and Inflammatory Bowel Disease
Day/Time: Sunday, October 11, 2020, 18:00-19:00 CET
Oral presentation: OP058
Title: The Incremental Increasing Rate of Thromboembolic Events in Patients with Inflammatory Bowel Disease Compared to Patients Without Autoimmune Disorder
Event: Virtual poster exhibition
Etrasimod (APD334) is a once-daily, oral, highly selective sphingosine 1-phosphate (S1P) receptor modulator, discovered by Arena, designed to provide systemic and local cell modulation by targeting S1P receptor subtypes 1, 4 and 5. Etrasimod has therapeutic potential in immune and inflammatory-mediated diseases such as ulcerative colitis, Crohn's disease, and atopic dermatitis. S1P receptors have been demonstrated to be involved in the modulation of several biological responses, including lymphocyte trafficking from lymph nodes to the peripheral blood. By isolating subpopulations of lymphocytes in lymph nodes, fewer immune cells are available in the circulating blood to effect tissue damage.
Olorinab (APD371) is an oral, peripherally acting, highly selective, full agonist of the cannabinoid type 2 receptor (CB2). Olorinab is an internally discovered investigational drug candidate that Arena is exploring for development in several indications, with an initial focus on visceral pain in gastrointestinal disorders. This compound, through its selectivity for CB2, versus the cannabinoid type 1 receptor (CB1), was designed to provide pain relief while minimizing the risk of psychoactive adverse effects.
Etrasimod and olorinab are investigational compounds that are not approved for any use in any country.
In a rapidly changing global market, we work with a sense of urgency every day to understand the needs of all our stakeholders, identify bold, sometimes disruptive, ideas to get our medicines to patients, and relentlessly execute until it's done.
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Certain statements in this press release are forward-looking statements that involve a number of risks and uncertainties. Such forward-looking statements include statements about Arena's participation in UEG Week, including its symposium, and data presentations; the opportunity, development and potential of etrasimod and olorinab; and Arena's purpose, work, understanding, ideas, and execution. For such statements, Arena claims the protection of the Private Securities Litigation Reform Act of 1995. Actual events or results may differ materially from Arena's expectations. Factors that could cause actual results to differ materially from the forward-looking statements include those disclosed in Arena's filings with the
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