February 10, 2005

Arena Pharmaceuticals to Announce Fourth Quarter and Full Year of 2004 Financial Results on Wednesday, February 16, 2005, and to Host Conference Call and Webcast on Thursday, February 17, 2005

SAN DIEGO, Feb. 10 /PRNewswire-FirstCall/ -- Arena Pharmaceuticals, Inc. (Nasdaq: ARNA) today announced that the company will release its financial results for the fourth quarter and full year ended December 31, 2004, after the NASDAQ National Market closes on Wednesday, February 16, 2005. Arena also announced today that Jack Lief, President and Chief Executive Officer of Arena, will host a conference call to discuss the financial results from the fourth quarter and full year of 2004 and corporate highlights. The call will take place on Thursday, February 17, 2005, at 9:00 AM Eastern Time (6:00 AM Pacific Time).

The conference call may be accessed by dialing (800) 762-4717 for domestic callers and (480) 629-9025 for international callers. Please specify to the operator that you would like to join the "Arena Pharmaceuticals Fourth Quarter Earnings Conference Call." The conference call will be webcast live on Arena's website at http://www.arenapharm.com, under the investor relations section, and will be archived there for 30 days following the call. Please connect to Arena's website several minutes prior to the start of the conference call to ensure adequate time for any software download that may be necessary.

About Arena Pharmaceuticals

Arena is a clinical-stage biopharmaceutical company focusing on the discovery, development and commercialization of drugs in four major therapeutic areas: metabolic, cardiovascular, inflammatory and central nervous system diseases. Arena is developing a broad pipeline of compounds that act on an important class of drug targets called G protein-coupled receptors, or GPCRs, and that are being developed using Arena's proprietary technologies, including CART (Constitutively Activated Receptor Technology) and Melanophore. Arena's most advanced clinical compound, APD356, a selective 5-HT2C serotonin receptor agonist for the treatment of obesity, is in a Phase 2 clinical trial that is expected to enroll 400 obese patients. Arena is also conducting a Phase 1 clinical trial on APD125, a compound with a novel mechanism of action (selective 5-HT2A receptor antagonism), for the treatment of insomnia. Arena has research collaborations with Ortho-McNeil Pharmaceutical, Inc., Merck & Co., Inc., and other companies for products in a number of different indications.

Forward-Looking Statements

Certain statements in this press release are forward-looking statements that involve a number of risks and uncertainties. Such forward-looking statements include statements about enrolling patients in a Phase 2 trial for APD356 and about Arena's expectations, strategy, technologies, preclinical and clinical programs, and ability to identify and develop drugs, as well as other statements that are not historical facts. For such statements, Arena claims the protection of the Private Securities Litigation Reform Act of 1995. Actual events or results may differ materially from Arena's expectations. Factors that could cause actual results to differ materially from the forward-looking statements include, but are not limited to, the timing, success and cost of Arena's research, out-licensing endeavors and clinical studies, Arena's ability to obtain additional financing, and the timing and receipt of payments and fees, if any, from Arena's collaborators, including Ortho-McNeil and Merck. Additional factors that could cause actual results to differ materially from those stated or implied by Arena's forward-looking statements are disclosed in Arena's filings with the Securities and Exchange Commission. These forward-looking statements represent Arena's judgment as of the time of this release. Arena disclaims any intent or obligation to update these forward-looking statements, other than as may be required under applicable law.

Arena Pharmaceuticals® and Arena® are registered service marks of the company. CART is an unregistered service mark of the company.

SOURCE Arena Pharmaceuticals
02/10/2005
CONTACT: Jack Lief, President & CEO of Arena Pharmaceuticals, +1-858-453-7200; or Susan Neath, Media & Investor Relations of Atkins + Associates, +1-858-527-3486, for Arena Pharmaceuticals
Web site: http://www.arenapharm.com


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