Arena Pharmaceuticals, Inc.
Oct 18, 2001

Arena Pharmaceuticals Announces Increased Revenues for 2001 Third Quarter and Nine Months Results

SAN DIEGO, Oct. 18 /PRNewswire/ -- Arena Pharmaceuticals, Inc. (Nasdaq: ARNA) today reported revenues of $3.5 million for the quarter ended September 30, 2001, a 50% increase over third quarter 2000 revenues, and $12.2 million for the nine months ended September 30, 2001, a 238% increase over the nine months ended September 30, 2000. Increased revenues in the third quarter and the first nine months of 2001 were primarily attributable to collaborations, which included research funding, milestone payments and technology access and development fees. The Company reported a net loss for the third quarter and first nine months of 2001 of $2.0 million, or $.07 per share, and $4.1 million, or $.17 per share, after non-cash accounting and amortization charges of $1.5 million and $4.3 million, respectively. This compares with prior year losses for the third quarter and first nine months, before any preferred stock charges, of $1.4 million, or $.07 per share and $7.4 million, or $.47 per share, on a pro forma basis, respectively.

Research and development expenses increased to $6.2 million in the third quarter of 2001 as compared to $3.5 million in the third quarter of 2000. For the nine months ended September 30, 2001, research and development expenses increased by $6.9 million to $15.4 million from $8.5 million for the nine months ended September 30, 2000.

Cash and cash equivalents totaled $239.5 million at September 30, 2001 and reflect the net proceeds from the Company's secondary offering, including the exercise of the over-allotment option, totaling $123.0 million that was completed in June 2001.

"Arena initiated Project Genesis as a defined internal research focus earlier this year. We believe that we have made significant progress toward our Project Genesis goals of acquisition, mapping, and completion of medicinal discovery at all G protein-coupled receptor targets. We believe that this significant scientific undertaking is important for Arena's long term success and growth," said Jack Lief, President and CEO. "We expect that the information that we are developing from Project Genesis will significantly help to both enhance the value of our proprietary CART Technology deals and to provide Arena with the ability to select interesting targets for our own internal drug development. We believe Arena's year to date performance is on track to achieve both its revenues and earnings guidance as well as the discovery of many new and exciting drug leads."

Arena's CART and Melanophore technologies allow for the direct identification of modulators of G protein-coupled receptors ("GPCRs") in a ligand-independent manner, making the technologies particularly useful with respect to the estimated 800 therapeutically relevant GPCRs within the human genome. Such ligand-independent screening is made possible by proprietary genetic alteration of these receptors. Arena has initiated "Project Genesis," an internal program aimed at obtaining all of the human GPCRs, identifying the location of these receptors within the human body for purposes of understanding the function of such receptors, and screening each GPCR to identify receptor modulators that form the basis of drug candidates. Arena expects to use its CART Technology, in conjunction with its Melanophore Technology, which Arena believes provides a unique screening technique that eliminates the need for radioactive or fluorescent screening to complete Project Genesis within the next three to five years.

Certain statements in this press release are forward-looking statements that involve a number of risks and uncertainties. Such forward-looking statements include statements about Arena's expected revenues, earnings and financial results, Arena's ability to obtain drug targets for its own internal drug development and statements that are not historical facts, including statements which are preceded by, followed by, or that include the words "intends," "will," "plans," "expects," "anticipates," "estimates," "aim" and "believes" or similar words. For such statements, Arena claims the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995. Actual events or results may differ materially from Arena's expectations and reported results should not be considered as an indication of future performance. Important factors that could cause actual events or results to differ materially from those stated or implied by Arena's forward-looking statements include, but are not limited to, the following: the ability to complete Project Genesis, if at all, within a reasonable time period; future quarterly or annual financial results; the timing, success and cost of preclinical research, out-licensing endeavors and clinical studies, and receipt of additional milestone payments, if any, from collaborators. Additional risk factors that could cause actual events or results to differ materially from those in Arena's forward-looking statements are disclosed in Arena's SEC reports, including, but not limited to, Arena's registration statement filed on June 21, 2001 on Form S-1, as amended, most recent quarterly report on Form 10-Q, and most recent annual report on Form 10-K. These forward-looking statements represent Arena's judgment as of the date of this release. Arena disclaims, however, any intent or obligation to update these forward-looking statements.

                           Arena Pharmaceuticals, Inc.
                 Condensed Consolidated Statements of Operations

                           Three months ended          Nine months ended
                             September 30,               September 30,
                           2001          2000          2001          2000
                        (unaudited)  (unaudited)   (unaudited)   (unaudited)

     Revenues
      Total revenues    $3,472,338    $2,314,126  $12,194,928     $3,603,397
     Expenses
     Research and
      development        6,230,959     3,465,360   15,375,823      8,546,347
     General and
      administrative     1,462,779       800,383    3,820,335      1,719,883
     Amortization of
      non-cash deferred
      compensation       1,071,653     1,123,358    3,413,050      2,952,402
     Amortization of
      acquired technology
      and other purchased
      intangibles          384,249            --      896,581             --
      Total expenses     9,149,640     5,389,101   23,505,789     13,218,632
     Interest and other
      income, net        3,657,748     1,656,381    7,230,621      2,188,359
     Net loss           (2,019,554)   (1,418,594)  (4,080,240)    (7,426,876)
     Non-cash preferred
      stock charge              --            --           --    (22,391,068)

     Net loss applicable
      to common
      stockholders     $(2,019,554)  $(1,418,594) $(4,080,240)  $(29,817,944)
     Net loss per share,
      basic and diluted     $(0.07)       $(0.09)       $(0.17)       $(4.91)
     Shares used in
      calculating net
      loss per share,
      basic and diluted 27,236,326    15,706,593   24,194,049      6,069,278
     Pro forma net loss
      per share                           $(0.07)                     $(1.89)
     Shares used in
      calculating pro
      forma net loss per
      share                           19,571,378                  15,801,764
Note: The loss per share on a pro forma basis assumes the conversion of
the redeemable preferred stock into common stock as of the date of
issuance. The redeemable preferred stock converted into common
stock at the closing of the Company's initial public offering on a
one-for-one basis.


    Condensed Consolidated Balance Sheet Data: September 30,   December 31,
                                                    2001           2000
                                                (unaudited)

     Assets
      Cash and cash equivalents                 $239,546,307   $144,413,176
      Other current assets                         5,899,799      3,801,268
      Property and equipment, net                 14,436,105      4,265,260
      Acquired technology, investments and other
       assets                                     19,696,873        232,225
       Total assets                             $279,579,084   $152,711,929
     Liabilities and Stockholders' Equity
      Liabilities                                 $8,257,855     $3,927,604
      Stockholders' equity                       271,321,229    148,784,325
       Total liabilities and stockholders'
        equity                                  $279,579,084   $152,711,929



"Arena Pharmaceuticals" is a registered U.S. trademark of the company. "Arena" and "CART" are trademarks of the company. Arena's headquarters are located at 6166 Nancy Ridge Drive, San Diego, CA 92121. Arena's telephone number is (858) 453-7200. On the Internet, please refer to Arena's website: http://www.arenapharm.com or BRL Screening's website: http://www.brlscreening.com for further information regarding CART Technology and the Melanophore Technology.

For further information, contact:

Jack Lief, President & CEO: Extension 223
Joseph Mooney, CFO: Extension 508

SOURCE Arena Pharmaceuticals, Inc.

CONTACT: Jack Lief, President & CEO, Extension 223, or Joseph Mooney, CFO, Extension 508, both of Arena Pharmaceuticals, Inc./